• Testosterone patch reduces angina

English KM et al. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina. A randomized, double-blind, placebo-controlled study. Circulation 2000 Oct 17;102(16):1906-11

  • Testosterone increases blood flow and aids chest pain

Rosano GM et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 1999 Apr 6;99(13):1666-70

  • Low T  = 3.3x risk of premature Coronary Artery Disease

Turhan S et al.The association between androgen levels and premature coronary artery disease in men. Coron Artery Dis. 2007 May;18(3):159-62.

  • Testosterone  increases coronary blood flow

Webb CM et. al Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation.1999 Oct 19;100(16):1690-6.


  • The higher the T level, the lower the Blood Pressure

Khaw KT, Barrett-Connor EJ. Blood Pressure and endogenous testosterone in men: an inverse relationship. Hypertens. 1988 Apr;6(4):329-32

  • Testosterone & metabolic syndrome

Syartberg J. Epidemiology: testosterone and the metabolic syndrome. Int J Impot Res.2006 Jul 20

  • Testosterone improves insulin resistance & diabetes

Boyanov MA, Boneva Z, Christov VG Aging Male 2003 Testosterone supplementation in men with type 2 diabetes, obesity and partial androgen deficiency.

  • Testosterone improves cognitive function

Alexander GM, Swerdloff RS, Wang C, etal. Androgen-behavior correlations in hypogonadal men and eugonadal men.ll. Cognitive abilities. Hormones and behavior 1998; 33(2):85-94

Barrett-Connor E et al. Endogenous sex hormones and cognitive function in older men. J Clin Endocrinol Metab 1999 Oct;84 (10):3681-5 J Clin Endocrinol Metab. 2002 Nov;87(11):5001-7 (memory)

  • Testosterone improves cognitive-cerebral blood flow

Moffat SD, Resnick SM. Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men.

Neurobiol Aging. 2006 May 11

  • Testosterone improved memory in Alzheimer’s

Tan RS A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer’s disease. Aging Male. 2003 Mar;6(1):13-7

Proc Natl Acad Sci USA 2000 Feb 1;97(3):1202-5

  • Testosterone improves depression

Am J Psychiatry 2003, Jan;1601(1):105-111

Am J Psychiatry 157:1884, Nov 2000

J Geniatr Psychiatry Neurology 2000 Summer;13(2):93-101

Cooper MA. Testosterone Replacement Therapy for Anxiety Am J Psychiatry 157:1884, November 2000

  • Testosterone increases spontaneous erections

Burris A et al. A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J Androl 1992 Jul-Aug;13(4):297-304

  • Myth of cancer

Tech Urol 2000 Sep;6(3):236-9 (Low IGF-1 assoc with prostate cancer)

  • NEJM Testosterone review

Rhoden El, et al. Medical Progress: Risks of testosterone replacement therapy and recommendations for monitoring N Engl J Med 2004;350:492Jan 29,2004

  • Testosterone does not cause enlarged prostate

Rhoden NEJM 2004

  • 18 prospective studies No assoc T therapy & Cancer

Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies Endogenous Hormones and Prostate Cancer Collaborative Group. J Natl Cancer Inst 2008100:170-183

  • 16 studies TRT does not cause increased risk of Cancer

Gould DC, Kirby RS testosterone replacement therapy for late onset hypogonadism: what is the risk of inducing prostate cancer?

Prostate Cancer Prostatic Dis. 2006;9(1):14-8

  • TRT & Cancer over 15 years

Feneley MR et al. PSA monitoring during Testosterone replacement therapy: low long-term risk of prostate cancer with improved opportunity for cure. Andrologia 2004; 36:212

  • No adverse effects of T on prostate

Marks LS et al. Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial JAMA. 2006 Nov 15;296(19):2369-71

  • Treating with T after Radical Prostatectomy for PC

Agarwal PK et al. Testosterone replacement therapy after primary treatment for prostate cancer. J Urol. 2005 Feb;173(2):533-6.

  • Low GH associated with disease

J Clin Endocrinal Metab 2001 Sep;86(9):4139-46

J Clin Endocrinal Metab 1999 Jun;84(6):1919-24

Acta Physial Scand 1999 Dec;167(4):347-50


  • Low GH associated with disease

JAMA 2000 Aug 16;284(7):879-81

Gerontology 2002 Nov-Dec;48(6):401-7

J Clin Endocrinol Metab 84:471-7,1999

J Clin Endocrin Metab. 2004Jan;89(1):114-20


  • GH improves action of testosterone

Blackman M, et al. JAMA Nov. 13,2002 Vol. 288 No 18 (GH and sex steroids in healthy men and women age 65-88 26 weeks, Gh 20mcg/kg3X/week, for 70 kg=12.6IU/week

  • GH improves brain function

Front Neuroendocrinol 2000 Oct;21(4):330-348

  • GH improves brain function

J Neuroscience, mar 15,2001,21(6):1902-1910

  • GH reverses osteoporosis

Logobardi, J Endocrinol Invest May 1999

Endocrinol, Apr 1998, p1899-1904 Vol 139, no4

Eur J Endocrinol 2000, Nov;143(5):585-592

Ann Intern Med 1996 Dec1;125(11):883-890

  • GH decreases atherosclerosis

J Endocrin Metab 1999 August (Effects of 10 years of GH)

J Clin Endocrin Metab 1999, 84:1329-1333,453-457

J Clin Endocrin and Metab, 2001, Vol86, No4 1518-152(RCT)

Ann Intern Med 2000 Jul 18;133(2):111-22(RCT in men)

Am Heart J 2002 Aug;144(2):359-64(reduction of cytokines in CHF)

J Clin Endocrin Metab 1997;82:727-734

  • GH increases heart function

J Endocrin Metab 1999 August

J Clin Endocrin Metab 1999, 84:1329-1333,453-457

J Card Surg 2001;16:127-131 (dilated cardiomyopathy improved if IGF-1 increased>80 by 7%

Arq Bras Cardiol 1999 Oct; 73(4):391-8

  • GH improves immune function

Endocr Rev. 1997 Apr;18(2):157-7

Neuroimmunomodulation 1999 Jan-Apr;6(1-2):56-58

  • GH corrects changes in body composition

Christiansen, J Effects of GH upon body composition. Growth Hormonein adults, 1996, Cambridge University press

Horm Res 2000 Jul, 53 Suppl 51:87-97(GH and adipocyte function)

J Clin Endocrin Metab 1997;82:727-734 (GH Rx of abdominally obese men also found improved BP and cholesterol)

Clin Endocrin Metab 2004 Feb, 89(2):695-701

  • GH improves quality of life

Clin Endocrinol (oxf) 2002 Sep;57(3):363-70

Cappola et al. JCEM, May 2003

  • No link between GH & cancer

Vance M, et al, GH therapy in adults and children. NEJM Oct 14, 1999

J Clin Endocrin Metab 2002 feb;87(2):473-6

Horm Res 1997;48Suppl4:29-32 (GH Therapy and Maligancy)

J Clin Endo Metab May 2001

J Clin Endocrin Metab Vol 85, No 12,Dec 2000

  • GH Diagnosis

Ann Intern Med 2002 Aug 6;137(3):202-204

  • GH Diagnosis

Horm Res 2000;53 Suppl 3:37-41

J Clin Endocrin Metab 2002 Feb;87(2),473-476

  • Arguments for GH therapy

Cook DM. Ann intern Med 2002 Aug 6;137(3):197-201

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RegenX Medical Institute. All Rights Reserved. No prescription will be provided unless a clinical need exists based on required lab work, physician consultation, physical examination, and current medical history. Please note agreeing to lab work and physical exam does not guarantee a finding of clinical necessity neither a prescription for hormone therapy. The statements on this website have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. No claim or opinion on this website is intended to be nor should it be construed to be medical advice or hormone diagnosis. Per state and federal laws medication can not be returned once it has been shipped from the pharmacy.