• Testosterone patch reduces angina

English KM et al. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina. A randomized, double-blind, placebo-controlled study. Circulation 2000 Oct 17;102(16):1906-11

  • Testosterone increases blood flow and aids chest pain

Rosano GM et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 1999 Apr 6;99(13):1666-70

  • Low T  = 3.3x risk of premature Coronary Artery Disease

Turhan S et al.The association between androgen levels and premature coronary artery disease in men. Coron Artery Dis. 2007 May;18(3):159-62.

  • Testosterone  increases coronary blood flow

Webb CM et. al Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation.1999 Oct 19;100(16):1690-6.

 

  • The higher the T level, the lower the Blood Pressure

Khaw KT, Barrett-Connor EJ. Blood Pressure and endogenous testosterone in men: an inverse relationship. Hypertens. 1988 Apr;6(4):329-32

  • Testosterone & metabolic syndrome

Syartberg J. Epidemiology: testosterone and the metabolic syndrome. Int J Impot Res.2006 Jul 20

  • Testosterone improves insulin resistance & diabetes

Boyanov MA, Boneva Z, Christov VG Aging Male 2003 Testosterone supplementation in men with type 2 diabetes, obesity and partial androgen deficiency.

  • Testosterone improves cognitive function

Alexander GM, Swerdloff RS, Wang C, etal. Androgen-behavior correlations in hypogonadal men and eugonadal men.ll. Cognitive abilities. Hormones and behavior 1998; 33(2):85-94

Barrett-Connor E et al. Endogenous sex hormones and cognitive function in older men. J Clin Endocrinol Metab 1999 Oct;84 (10):3681-5

J Clin Endocrinol Metab. 2002 Nov;87(11):5001-7 (memory)

  • Testosterone improves cognitive-cerebral blood flow

Moffat SD, Resnick SM. Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Neurobiol Aging. 2006 May 11

 

  • Testosterone improved memory in Alzheimer’s

Tan RS A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer’s disease. Aging Male. 2003 Mar;6(1):13-7

Proc Natl Acad Sci USA 2000 Feb 1;97(3):1202-5

  • Testosterone improves depression

Am J Psychiatry 2003, Jan;1601(1):105-111

Am J Psychiatry 157:1884, Nov 2000

J Geniatr Psychiatry Neurology 2000 Summer;13(2):93-101

Cooper MA. Testosterone Replacement Therapy for Anxiety Am J Psychiatry 157:1884, November 2000

 

  • Testosterone increases spontaneous erections

Burris A et al. A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J Androl 1992 Jul-Aug;13(4):297-304

  • Myth of cancer

Tech Urol 2000 Sep;6(3):236-9 (Low IGF-1 assoc with prostate cancer)

  • NEJM Testosterone review

Rhoden El, et al. Medical Progress: Risks of testosterone replacement therapy and recommendations for monitoring N Engl J Med 2004;350:492Jan 29,2004

  • Testosterone does not cause enlarged prostate

Rhoden NEJM 2004

  • 18 prospective studies No assoc T therapy & Cancer

Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies Endogenous Hormones and Prostate Cancer Collaborative Group. J Natl Cancer Inst 2008100:170-183

  • 16 studies TRT does not cause increased risk of Cancer

Gould DC, Kirby RS testosterone replacement therapy for late onset hypogonadism: what is the risk of inducing prostate cancer?

Prostate Cancer Prostatic Dis. 2006;9(1):14-8

  • TRT & Cancer over 15 years

Feneley MR et al. PSA monitoring during Testosterone replacement therapy: low long-term risk of prostate cancer with improved opportunity for cure. Andrologia 2004; 36:212

  • No adverse effects of T on prostate

Marks LS et al. Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial JAMA. 2006 Nov 15;296(19):2369-71

  • Treating with T after Radical Prostatectomy for PC

Agarwal PK et al. Testosterone replacement therapy after primary treatment for prostate cancer. J Urol. 2005 Feb;173(2):533-6.

  • Low GH associated with disease

J Clin Endocrinal Metab 2001 Sep;86(9):4139-46

J Clin Endocrinal Metab 1999 Jun;84(6):1919-24

Acta Physial Scand 1999 Dec;167(4):347-50

 

  • Low GH associated with disease

JAMA 2000 Aug 16;284(7):879-81

Gerontology 2002 Nov-Dec;48(6):401-7

J Clin Endocrinol Metab 84:471-7,1999

J Clin Endocrin Metab. 2004Jan;89(1):114-20

 

  • GH improves action of testosterone

Blackman M, et al. JAMA Nov. 13,2002 Vol. 288 No 18 (GH and sex steroids in healthy men and women age 65-88 26 weeks, Gh 20mcg/kg3X/week, for 70 kg=12.6IU/week

  • GH improves brain function

Front Neuroendocrinol 2000 Oct;21(4):330-348

  • GH improves brain function

J Neuroscience, mar 15,2001,21(6):1902-1910

  • GH reverses osteoporosis

Logobardi, J Endocrinol Invest May 1999

Endocrinol, Apr 1998, p1899-1904 Vol 139, no4

Eur J Endocrinol 2000, Nov;143(5):585-592

Ann Intern Med 1996 Dec1;125(11):883-890

  • GH decreases atherosclerosis

J Endocrin Metab 1999 August (Effects of 10 years of GH)

J Clin Endocrin Metab 1999, 84:1329-1333,453-457

J Clin Endocrin and Metab, 2001, Vol86, No4 1518-152(RCT)

Ann Intern Med 2000 Jul 18;133(2):111-22(RCT in men)

Am Heart J 2002 Aug;144(2):359-64(reduction of cytokines in CHF)

J Clin Endocrin Metab 1997;82:727-734

  • GH increases heart function

J Endocrin Metab 1999 August

J Clin Endocrin Metab 1999, 84:1329-1333,453-457

J Card Surg 2001;16:127-131 (dilated cardiomyopathy improved if IGF-1 increased>80 by 7%

Arq Bras Cardiol 1999 Oct; 73(4):391-8

  • GH improves immune function

Endocr Rev. 1997 Apr;18(2):157-7

Neuroimmunomodulation 1999 Jan-Apr;6(1-2):56-58

  • GH corrects changes in body composition

Christiansen, J Effects of GH upon body composition. Growth Hormonein adults, 1996, Cambridge University press

Horm Res 2000 Jul, 53 Suppl 51:87-97(GH and adipocyte function)

J Clin Endocrin Metab 1997;82:727-734 (GH Rx of abdominally obese men also found improved BP and cholesterol)

Clin Endocrin Metab 2004 Feb, 89(2):695-701

  • GH improves quality of life

Clin Endocrinol (oxf) 2002 Sep;57(3):363-70

Cappola et al. JCEM, May 2003

  • No link between GH & cancer

Vance M, et al, GH therapy in adults and children. NEJM Oct 14, 1999

J Clin Endocrin Metab 2002 feb;87(2):473-6

Horm Res 1997;48Suppl4:29-32 (GH Therapy and Maligancy)

J Clin Endo Metab May 2001

J Clin Endocrin Metab Vol 85, No 12,Dec 2000

  • GH Diagnosis

Ann Intern Med 2002 Aug 6;137(3):202-204

  • GH Diagnosis

Horm Res 2000;53 Suppl 3:37-41

J Clin Endocrin Metab 2002 Feb;87(2),473-476

  • Arguments for GH therapy

Cook DM. Ann intern Med 2002 Aug 6;137(3):197-201